Lewis Smith

Lewis J. Smith, M.D. is Professor of Medicine, Director of the Center for Clinical Research in the Northwestern University Clinical and Translational Sciences Institute, and Associate Vice President for Research at Northwestern University.  He obtained an undergraduate degree from the City College of New York and a medical degree from the University of Rochester. He completed training in internal medicine at Strong Memorial Hospital in Rochester, N.Y. and in pulmonary medicine at Boston University. He joined the faculty of Northwestern University in 1979 and served as Chief of the Pulmonary and Critical Care Medicine Division from 1982 to 1998. He was Associate Director of the Office of Clinical Research and Training from 1988-2002, at which time he developed a training program in clinical investigation, which awards a Master of Science degree from the Graduate School.  

He has had active laboratory-based and clinical research programs with funding from the Department of Veterans Affairs, the NIH, foundations and industry.  For the past 30 years he has studied various aspects of asthma pathogenesis and treatment.  He did some of the initial studies exploring the role of leukotrienes and leukotriene modifiers in asthma.  He has been the Chicago site PI for the American Lung Association’s Asthma (now Airways) Clinical Research Centers (ALA-ACRC) program since its inception in 1999, corresponding PI for the Chicago center of the NHLBI-supported AsthmaNet program, and PI of a multicenter NIH-funded study exploring the role of soy isoflavones for the treatment of patients with poorly controlled asthma.  He has been involved in three large epidemiology studies (CARDIA, MESA, SOL) that have provided novel insights into the prevalence and incidence of airway diseases and the factors that contribute to and protect against the development of asthma and COPD.  He is currently leading an initiative to expand and enhance clinical research support throughout Northwestern and its clinical affiliates.  In his role as Associate Vice President for Research several University Research Centers report to him and he serves as a liaison between the University and the Feinberg School of Medicine for issues related to clinical and translational research.


Lewis Smith, MD
Northwestern University